1.
Chemistry
; 29(38): e202300255, 2023 Jul 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37092698
RESUMO
Ir-catalyzed transformations initiated by sulfur-directed vinylic sp2 and benzylic sp3 â C-H activation are disclosed that achieve the construction of sulfur-containing seven- and eight-membered systems. Allyl 2-alkynylphenyl sulfides were transformed into dihydrobenzothiepines in 30-95 % yield, and 2-alkynylaryl 2-tolyl sulfides were converted into dibenzo[b,f]thiepines in 57-95 % yield along with double bond isomerization. In both reactions, the combination of Ir catalyst and sulfide moiety was a key to the facile cyclization.